The Spindle Assembly Checkpoint Current Biology Biology Diagrams NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation Article Open access 09 December 2021. Surveillance of cohesin-supported chromosome structure controls Principles and dynamics of spindle assembly checkpoint signalling Spindle pole OFF ON MCC MCC APC/CCDC20 APC/CCDC20 Aurora B Anaphase onset Securin Cyclin B Separase CDK1 APC/CCDCc20
Accurate chromosome segregation and spindle positioning during cell division are critical for genomic stability, with these processes regulated by the spindle assembly checkpoint (SAC) and spindle positioning checkpoint (SPOC) [1], [2].The SAC ensures that chromosomes are properly attached to the spindle before anaphase, preventing premature separation and aneuploidy [3], [4], while the SPOC During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint
Dynamics of spindle assembly and position checkpoints: Integrating ... Biology Diagrams
Principles and dynamics of spindle assembly checkpoint signalling Article 24 March 2023. Introduction. The spindle, first described in the 1880s 1 by The spindle assembly checkpoint (SAC, also known as mitotic or metaphase checkpoint) is a feedback-control system that operates during cell division in eukaryotic cells 1, 2, 3.The SAC monitors chromosome bi-orientation on the mitotic spindle, and as long as improperly attached chromosomes remain, it halts cells in mitosis and precludes passage into the final phases of cell division (Figure 1). Before the cell can proceed further, to anaphase, a checkpoint mechanism, the spindle assembly checkpoint (SAC) determines that each member of a chromatid pair is correctly attached to the opposite spindle poles (Sear and Howard 2006; Musacchio and Salmon 2007). This is a tension-sensing mechanism: correct attachments are in a state of tension
Dynamics of spindle assembly and position checkpoints: Integrating molecular mechanisms with computational models Comput Struct Biotechnol J. 2025 Jan 10 including bistable switches driving spindle assembly checkpoint (SAC) activation, spatial organization principles underlying spindle position checkpoint (SPOC) signaling, and critical
