Retinoblastoma Protein Cell Cycle Biology Diagrams The retinoblastoma protein is an inhibitor of cell cycle progression from the G1 to the S phase of the cell cycle. It acts through its ability to interact with cellular target molecules such as E2F transcription factors. Hatakeyama, M., Weinberg, R.A. (1995). The role of RB in cell cycle control. In: Meijer, L., Guidet, S., Tung, H.Y.L Loss of cell-cycle control is a hallmark of neoplastic cells. One regulator of the critical G1 to S-phase transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which The retinoblastoma protein is an inhibitor of cell cycle progression from the G1 to the S phase of the cell cycle. It acts through its ability to interact with cellular target molecules such as E2F transcription factors. The role of RB in cell cycle control Prog Cell Cycle Res. 1995:1:9-19. doi: 10.1007/978-1-4615-1809-9_2. Authors M
The role of RB in cell cycle control Masanori Hatakeyama1,2 and Robert A. Weinbergl> The retinoblastoma protein is an inhibitor of cell cycle progression from the Gl to the S phase of the cell cycle. It acts through its ability to interact with cellular target molecules such as E2F transcription factors. The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of both RB alleles plays an essential, rate-limiting role in retinoblastoma and in the osteosarcomas that arise within families that carry a mutated RB gene.
cycle regulation and apoptosis Biology Diagrams
The RB gene was cloned more than 25 years ago 1.Since that time, its encoded protein has been identified as a universal cell cycle regulator with a central role in controlling the commitment of a cell to initiate DNA replication and divide 2.Eliminating RB function allows unregulated cell cycle progression and promotes tumour growth. The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes three memb โฆ The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a
Rb family proteins (pRb/p105, Rb2/p130 and p107) play a key role in cell cycle control and are worthily involved in transcription repression and tumor suppression. The mechanisms of
