Development of Personalized Therapeutic Biology Diagrams Cell cycle inhibitors such as CDK and checkpoint kinase inhibitors are often used in combination with chemotherapy to target cell cycle factors for cancer treatment [21, 124, 140, 141]. In addition to CDKs, checkpoint kinases like Aurora A/B and PLKs are other targets for cancer therapy. Here, we provide an overview on the role of CDK-cyclin complexes, metabolic adaptations and oxidative stress in regulating progression through each cell cycle phase and transitions between them. Thus, new approaches for the design of innovative cancer therapies targeting crosstalk between cell cycle simultaneous events are proposed.
Cell-cycle-targeting drugs have the advantages of high specificity, low toxicity, low side effects, and low drug resistance. Aberrant angiogenic signaling pathways: accomplices in ovarian cancer progression and treatment. Cell Signal 120, 111240. 10.1016/j.cellsig.2024.111240 [Google Scholar] Articles from Frontiers in Pharmacology are
Cell cycle checkpoint revolution: targeted therapies in the fight ... Biology Diagrams
Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in
Cell cycle regulation has an important influence on the proliferation, metastasis, and recurrence of tumor cells . In the current cancer treatment, the regulation of the cell cycle is mainly to control the expression of related genes and the activity of intracellular enzymes, proteins, or signal factors [5,6,7].
Targeting cell cycle regulation in cancer therapy Biology Diagrams
The cell cycle represents a series of tightly integrated events that allow the cell to grow and proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases (CDKs), which, when activated, provide a means for the cell to move from one phase of the cell cycle to the next. Targeting the cell cycle: a new approach to
